The complete fourth season of the award-winning US drama following the lives of medical professionals at the fictional Seattle Grace Hospital. In this season, Meredith (Ellen Pompeo), Cristina (Sandra Oh), Alex (Justin Chambers) and Izzie (Katherine Heigl) become residents while George (T.R. Knight) has to repeat his intern year. The episodes are: 'A Change Is Gonna Come', 'Love/Addiction', 'Let the Truth Sting', 'The Heart of the Matter', 'Haunt You Every Day', 'Kung Fu Fighting', 'Physical Attraction... Chemical Reaction', 'Forever Young', 'Crash Into Me: Part 1', 'Crash Into Me: Part 2', 'Lay Your Hands On Me', 'Where the Wild Things Are', 'Piece of My Heart', 'The Becoming', 'Losing My Mind' and 'Freedom'.

Thriller in which a weekend cruise on a luxurious party yacht goes horribly wrong for a group of old high-school friends when they forget to let the ladder down before they jump into the ocean for a swim. The boat proves impossible to climb and they are stuck in the water many miles from shore, with baby Sara left alone on board. Sara's mother Amy must contend with her aqua-phobia as well as the group's increasing desperation, as the friends begin to turn on each other. Soon the exhaustion of keeping afloat and the struggle to get back on board begin to take a terrible toll. The happy reunion turns into a fight for survival.